A number of ongoing phase III trials are investigating the use of sentinel node biopsy for early breast cancer. Areas covered include:
- treatment following identification of a positive sentinel node and micrometastases from sentinel node biopsy (AMAROS29 using radiotherapy; IBCSG-23-0130 randomising to further surgery or no further surgery for micrometastases)
- accuracy of sentinel node biopsy in large and/or multifocal tumours (SNAC II28)
- significance of micrometastases and isolated tumour cells (AMAROS,29IBCSG-2330).