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Follow up of women with epithelial ovarian cancer

The asymptomatic women with a rising CA125

Around 60-90% of asymptomatic women will have a rising CA125 that precedes detection of a clinical recurrence by 3-5 months.5 Where an asymptomatic woman has rising CA125 levels but no evidence of disease, for example on imaging, and where her reported quality of life is good, there is good reason to delay the initiation of any treatment based on the findings of Rustin et al.22 The decision to initiate re-treatment requires careful consideration based on the individual woman s situation, and factors including the eventual nature of the recurrence and the wishes of the woman.

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