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Recommendations for use of Bisphosphonates

Ongoing and Additional Trials or Studies

A number of additional studies are investigating the use of bisphosphonates for early breast cancer:

  • five trials investigating the use of bisphosphonates in combination with chemotherapy and/or hormone therapy for adjuvant treatment of early breast cancer (zoledronic acid: HOBOE,51 CZOL446GDE13;52 clodronate: NSABP B-34;53 ibandronate: GAIN,54 TEAM IIB55)
  • one trial investigating the use of zoledronic acid in combination with chemotherapy and/or hormone therapy for adjuvant or neoadjuvant treatment of high risk localised breast cancer (AZURE56)a
  • four trials investigating upfront versus delayed use of zoledronic acid in combination with chemotherapy and/or hormone therapy for adjuvant treatment of early breast cancer (NCT00376740,57 CFEM345D2405,58 CALGB-79809, 59b JPRN-UMIN00000110460)
  • one trial investigating the use of zoledronic acid in combination with letrozole for extended adjuvant treatment of primary breast cancer (CFEM345DDE0961)
  • one trial comparing zoledronic acid with clodronate or ibandronate for adjuvant treatment of early breast cancer in combination with chemotherapy and/or hormone therapy (SWOG-S030762)
  • two trials investigating the use of risedronate in preventing bone loss in postmenopausal women on hormonal therapy (REBBeCA II,63 RISAROS64)
  • three trials investigating the use of zoledronic acid in combination with chemotherapy and/or hormone therapy for neoadjuvant treatment of early breast cancer (CZOL446GDE19,65 CZOL446GCA08,66 ANZAC67)
  • one trial investigating the postoperative use of zoledronic acid in breast cancer patients after neoadjuvant chemotherapy (NATAN68).

a Preliminary results from AZURE were presented at San Antonio Breast Cancer Symposium 2010. Data on the safety profile of zoledronic acid were published in 2011

b Results from CALGB-79809 were published in 2011

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