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Recommendations for use of Bisphosphonates

Unanswered Questions

  • What is the optimal schedule and duration for use of bisphosphonates?
  • What are the longer-term effects of bisphosphonate use (beyond 15 years)?
  • What are the relative harms/benefits of different bisphosphonates?
  • How do bisphosphonates affect overall quality of life?
  • What baseline tests should be used to determine who could benefit from bisphosphonates?
  • Are there certain subgroups who would benefit most from different bisphosphonates?
  • What is the relationship between bisphosphonate type and dosage and osteonecrosis of the jaw?
  • What are the long term effects of improvements in bone mineral density on future bone events, such as fractures?
  • How do bisphosphonates compare with new bone acting agents?
  • How do bisphosphonates interact with newer breast cancer systemic treatments (such as targeted therapies)?
  • What is the role of biochemical markers to monitor bisphosphonate use?
  • What are the optimal tests and schedules for monitoring women taking bisphosphonates?

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