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Recommendations for use of Bisphosphonates

Ongoing and additional trials or studies

A number of additional randomised controlled trials investigating the use of bisphosphonates for advanced breast cancer are ongoing and/or awaiting results:

  • two ongoing trials comparing oral ibandronate to intravenous zoledronic acid (SWOG-S0308; ZICE)23-24
  • four ongoing trials comparing different schedules of zoledronic acid (BISMARK; CALGB-70604; NCT00320710; NCT00375427)25-28
  • one ongoing trial comparing single dose ibandronate to single dose radiotherapy for bone pain (ISRCTN86185157).29

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