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Recommendations for use of Endocrine therapy

Details of trials or studies

Table 1: Details of trials of endocrine therapy for post-menopausal women3
Trial Intervention Comparator Position in treatment sequence
Aromatase inhibitor vs antioestrogen
Bonneterre 2001 Anastrozole 1.0 mg/day Tamoxifen 20 mg/day First-line for advanced disease
Milla-Santos 2003 Anastrozole 1.0 mg/day Tamoxifen 40 mg/day First-line for advanced disease
Paridaens 2003/4 Exemestane 25 mg/day Tamoxifen 20 mg/day First-line hormonal therapy for metastatic disease (≤1 CT regimen permitted)
Mouridsen 2001 Letrozole 2.5 mg/day Tamoxifen 20 mg/day First-line hormonal therapy for metastatic disease (≤1 CT regimen permitted)
Batra 2006 Letrozole 2.5 mg/day Tamoxifen 20 mg/day First-line for metastatic or recurrent disease
Mauriac 2003 Anastrozole 1.0 mg/day Fulvestrant 250 mg/month IM Second-line after endocrine therapy
Gradishar 2006 Exemestane 25 mg/day Fulvestrant IM loading dose regimena Second-line after NSAI therapy
Aromatase inhibitor vs progestin
Buzdar 1996 [North American and European trials] Anastrozole 1.0 mg/day Megestrol acetate 160 mg/day Second-line after antioestrogen
Kaufmann 2000 [Trial EXE 018] Exemestane 25 mg/day Megestrol acetate 160 mg/day Second-line after antioestrogen
Buzdar 2001 Letrozole 2.5 mg/day Megestrol acetate 160 mg/day Second-line after antioestrogen
Schmid 2001 Letrozole 2.5 mg/day Megestrol acetate 160 mg/day Possibly second-lineb
Dombernowsky 1998 Letrozole 2.5 mg/day Megestrol acetate 160 mg/day Second-line after antioestrogen
Aromatase inhibitor vs aromatase inhibitor
Mayordomo 2006 [GEICAM 2001-03] Anastrozole 1.0 mg/day Exemestane 25 mg/day First-line hormonal for metastatic disease (previous CT permitted)
Rose 2003 Anastrozole 1.0 mg/day Letrozole 2.5 mg/day Second-line after antioestrogen

Notes: CT = chemotherapy; IM = intramuscular; NSAI = nonsteroidal aromatase inhibitor
a 500 mg on Day 0, 250 mg on Days 14 and 28, and 250 mg every 28 days thereafter
b Not explicitly stated in the publication

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